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Recent studies have implicated neuroinflammatory changes as being crucial in the development of ASD, with evidence of significant microglial activation and increased production of inflammatory cytokines and chemokines, including Interferon- (IFN-), IL-1, IL-6, and TNF- (159, 160)

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Inject slowly over 10-20 seconds

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A scheme integrating all MTX-modulated metabolites into a single metabolic panel can be found in Supplementary Figure 4

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and Mobile phase B: Acetonitrile

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This treatment is not for everyone

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coli strain BL21 as previously described 23

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