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Awareness of those potential treatment sites makes different options of approach possible in the patient with hepatic encephalopathy, and each approach should be personalized

Miller DE, Kunce JT (1973) Prediction and statistical overkill revisited

The role of Arc in synaptic plasticity and memory is complex and manifold (Nikolaienko et al., 2018) but one important function at synapses is to promote internalization of AMPARs and LTD via interaction with other post-synaptic proteins such as endophilin/dynamin (Okuno et al., 2012

These are typically dose-dependent and diminish with time and proper titration

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