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From an evolutionary perspective, dramatic weight loss signals potential starvation

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Bouligny I, Montalban-Bravo G, Sasaki K, Daver N, Jabbour E, Alvarado Y, DiNardo C, Ravandi F, Borthakur G, Bose P, Pemmaraju N, Kornblau S, Kadia T, Masarova L, Takahashi K, Andreeff M , Kanagal-Shamanna R, Hosing C, Pierce S, Meyer M, Huang X, Kantarjian H, Garcia-Manero G

As expected, the reactions with At LDOX also resulted in formation of epidihydroquercetin ( 9 ), dihydroquercetin ( 10 ) and quercetin ( 11 ), the known by-products of the investigated reaction 12,13 (Extended Data Figs

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each is optimized for a different priority