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Cox models for mortality and complications

Theres going to be an explosion in the sheer number of compounds Kumar has found he can design bias into GLP-1 analogues by simply alkylating or trifluoroalkylating the N -terminal amino acid using an alkyl halide

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These include: Nausea (particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite These effects are broadly consistent with the class effects seen with other GLP-1-based therapies

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