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The first is water soluble vitamins and the second is lipid-soluble vitamins which are also called fat soluble vitamins

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The authors also point out that in some rare genetic disorders of B12 metabolism, the active forms may be required, and that smokers, who tend to have an excess of thiocyanate in their blood, may benefit from a taking a form other than cyano-B12

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Science (2022) 378:192201