glp 1 oral vs injection Weight Loss Pills vs. Injections: Which Option Is Right for You? Injection vs pill is not

Study Design Type: Phase 2, double-blind, randomized, placebo-controlled study Participants: 338 adults (BMI 30 or BMI 27 with a coexisting condition) Groups: Retatrutide 1 mg, 4 mg, 8 mg, 12 mg (different initial doses 2 or 4 mg) and placebo Duration: 48 weeks (plus 4 weeks follow-up) Administration: subcutaneous, 1x weekly Primary endpoint: percentage change in body weight at week 24 Secondary endpoints: change in weight at week 48, 5%, 10%, 15% weight reduction

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GLP-1 action on target tissues Glu cagon-like pep tide -1 (GLP-1) is a hormone released from the gut after eating to decrease blood glucose by several mechanisms

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Gotardo, E

doi: 10.1016/j.jhepr.2019.07.002 188 SanyalAJ