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They all have an impact on how the lungs function, and overcoming their negative side effects helps enhance the effectiveness of medications used for lung therapy [23]

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Kawahara K, Sato T, Kawamura K, et al

For example, proinflammatory cytokines such as IL-1 have been shown to impair neurotransmitter homeostasis (e.g., decreased serotonin levels and enhanced glutamatergic excitotoxicity), induce oxidative stress (OS) and neuronal pyroptosis, and lead to mitochondrial dysfunction and synaptic protein lossultimately fostering a bidirectional relationship between epilepsy and depression (Zhu et al., 2006

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