In cases 6211, 6070 and 6245, more than 50% of insulin cells showed weak staining intensities for GPX1, while in case E560, approximately 75% of insulin cells displayed moderate staining intensities
Therefore, inhibitors of nuclear export have been shown to block cell death [149]
Hyperglycemia and the ensuing glucotoxicity exert their deleterious effects via myriad mechanisms, including ROS stress, ER stress, inflammation, and hypoxia 28
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