retatrutide phase 3 triumph Top Line results MEGATHREAD : r/Retatrutide Eli Lilly's New Weight-Loss Treatment

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The starting dose of retatrutide in clinical trials is 1 mg once weekly for the first 4 weeks

1mg dose: 8.7% average weight loss 4mg dose: 15.2% average weight loss 8mg dose: 21.1% average weight loss 12mg dose: 24.2% average weight loss Placebo: 2.1% average weight loss For practical context, a person starting at 220 pounds would lose approximately 53 pounds at the highest dose over 48 weeks

[16] [17] Close collaboration between primary care, endocrinology, and cardiology is essential for complex cases

Eli Lilly TRIUMPH-4 Phase 3 Trial Results

Women researchers typically use far lower doses, usually 5mg to 10mg weekly, focusing on the metabolic and body composition benefits while minimizing androgenic effects