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Each peptide targets different but complementary regenerative mechanisms, making the combination relevant for multi-pathway tissue repair research

Orexigenic neurons express neuropeptide Y (NPY) and agouti-related peptide (AgRP), whereas anorexigenic neurons express pro-opiomelanocortin (POMC)

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Increased infiltration of local neutrophil extracellular traps (NETs) around intestinal microvasculature, accompanied by increased ferroptosis of endothelial cells, was detected in both intestinal I/R patients and animal models, which may be a major cause of microcirculation dysfunction

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Proglucagon-derived peptides: Mechanisms of action and therapeutic potential