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7 In these emergency situations, a single low dose of rasburicase (0.02 to 0.05mg/kg up to 3mg) can be administered and it is recommended that hemodialysis be readily available in the event of clinically significant hemolysis and acute renal failure

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Mechanisms that commonly induce ROS generation in viral infections include the deregulation of mitochondrial function, activation and upregulation of NOX production, and modification of the Nrf2/ARE pathway, with superoxide being the most commonly produced ROS 55

The accepted mechanism of action underlying the sex-specific rodent liver response to APAP is the faster rate of de novo GSH synthesis in females compared to males

Supporting this, Kuria et al., in a sub-analysis, reported a significant reduction of cardiovascular mortality in studies conducted in Asia (RR 0.59

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