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When PK is highly active, the rate of mitochondrial ATP production via oxidative phosphorylation is reduced as a result of reduced ADP transport into the mitochondria

Disclosure The author was the subject of this open label case study

This means that EpCAM-specific antibodies are conjugated with cytotoxic agents, such as doxorubicin, paclitaxel, calicheamicin, topoisomerase I inhibitors, alpha amanitin, and indolinobenzodiazepine pseudodimers (IGNs), to specifically kill the EpCAM+ tumor cells

Deficiencies in iron, zinc, biotin, and vitamin D commonly contribute to hair loss and should be addressed alongside any treatment protocol

& Millar, N

Synthesis and characterization of platinum(IV) anticancer drugs with functionalized aromatic carboxylate ligands: influence of the ligands on drug efficacies and uptake