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Both Eli Lilly and Novo Nordisk have spent billions of US dollars to meet the growing demand for their blockbuster drugs

That interpretation of the rules is being challenged in the courts by Novo Nordisk and Eli Lilly, which makes rival weight-loss therapy tirzepatide, while the compounders have countersued, claiming that the FDA's removal of the drugs from the shortages list was premature

These limitations include cytotoxicity, immune rejection, regulatory obstacles, senescence and inflammation, and limited targeting precision [10, 58, 59]

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