If lumps develop: These are usually localized swelling, not dangerous
For a time, GLP-1 medications were in short supply, which contributed to the rise of compounding
What Caloric Restriction Does to Cellular Energy Your cells produce energy through the mitochondria, using a process that requires a steady supply of fuel and specific molecular cofactors including NAD+
centrally-mediated loss of appetite & increased thermogenic activity GLP-1 receptors are found in regions of the hindbrain and hypothalamus that regulate feeding behavior Centrally mediated GLP-1 effects include: reduction of food intake - resulting in weight loss due to reduced caloric intake activation of sympathetic pathways in the dorsomedial hypothalamus (DMH) and ventromedial nucleus of the hypothalamus (VMH) that increase neuronally mediated thermogenic activity of brown adipose tissue (BAT) resulting in increased energy expenditure with associated weight loss (Contreras et al, 2017
Zepbound is approved for chronic weight management in certain adults, while Mounjaro is approved to improve blood sugar control in adults with type 2 diabetes
GLP-1s help quiet inflammatory signals in the gut that are known to influence how we cope with stress and cravings so when that quieting signal disappears...emotional regulation can wobble right alongside your appetite
