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The gastrointestinal tract plays a key role in Mn uptake, mediated by metal transporters, and these transporters can also contribute to Mn excretion via the gastrointestinal tract and the hepatobiliary system (Mercadante et al., 2019

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10.1007/s11240-006-9133-z Plant Cell Tissue Organ Cult

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Interaction with Epithalon leads to the activation of several genes, including the gene MMP2 found also in the skin that regulates this protein, as well as the activation of fibroblasts producing and maintaining MMP2