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Metformin, a biguanide, has been a cornerstone of type 2 diabetes pharmacotherapy for decades, with an established safety profile and extensive clinical experience

JAAD Int 2021

Retatrutide works by simultaneously activating three key metabolic pathways: GLP-1 receptor agonism enhances insulin secretion, reduces appetite, and slows gastric emptying

Initial testing may also be covered in some situations

Individuals with a personal or family history of medullary thyroid carcinoma or MEN2 are typically excluded from trials due to precautionary class-effect concerns

Coverage Varies Dramatically by State Only 13 state Medicaid programs currently cover Wegovy for weight loss