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Semaglutide-associated bullous pemphigoid

Here is where retatrutide and tirzepatide diverge in ways that matter

The phase 3b STEP UP obesity trial in more than 1,400 patients compared a 7.2mg weekly subcutaneous injection of semaglutide to the standard 2.6mg weekly dose sold as Wegovy or a matched placebo over 72 weeks

Side effects have resolved: Doctors are more likely to increase your dose once any initial digestive issues, such as mild nausea or constipation, have subsided

Emili et al., 2022

It is the average across the entire highest-dose group, with some individuals losing well over 30% of their starting body weight