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The elevated histamine level in KOA IFP was reflected in altered histidine metabolism pathway and may relate to higher inflammatory responses in our KOA patients, who had not used immunosuppressive medication, unlike the RA patients

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Intravenous iron injections in severe cases, or if oral pills are not effective

It exists in two main forms: eumelanin (which is darker, usually brown or black) and pheomelanin (which is lighter, often yellow or red)

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