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L-citrulline converts into L-arginine and is often easier to tolerate

It appears to do this partly by breaking disulfide bonds in mucus proteins, making secretions less sticky and easier to clear.30 Researchers have also studied NAC in chronic bronchitis and COPD because oxidative stress and inflammation play a role in airway irritation and flare-ups

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it similarly reported small effects corresponding to a 12% absolute increase in response (number needed to treat (NNT) 9) and an SMD of 0.20 versus placebo for adjunctive antidepressants [15]

This does not alter the authors' adherence to the PLOS ONE policies on data sharing and materials

Lifestyle Factors Complementary strategies that may support outcomes alongside the protocol