Other notable adverse effects include: Injection site reactions such as erythema, pruritus, or swelling Fatigue reported in approximately 5% to 6% of patients Hypoglycemia when used in combination with insulin or sulfonylureas Increased heart rate with modest elevations of 2 to 4 beats per minute (a class effect of incretin therapies with uncertain clinical significance) Serious but rare adverse effects include acute pancreatitis, gallbladder disease (cholelithiasis, cholecystitis), acute kidney injury (typically secondary to dehydration from gastrointestinal symptoms), and hypersensitivity reactions
GLP-1 medications are extremely powerful medications, so side effects and adverse events can occur when theyre prescribed to poorly selected patients without education, close monitoring, and support, says Saunders
1 2 Lancet
Evoking picomolar binding in RNA by a single phosphorodithioate linkage
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