In the subgroups of patients with T2DM and received SEM as the second-line therapy (add-on to MET), treatment with either dose of SEM for 30 weeks to 56 weeks was associated with greater reduction in BMI, compared with SIT, EXE, or IG (Table 31)
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Beresford, T
While tirzepatide already exists as an incretin-based drug with superior weight loss outcomes, an oral formulation like orfoglipron could may increase treatment acceptability and adherence
F., Hou, Y., Lautrup, S., et al
In adults and older children, the total volume used should also stay within safe limits animal studies suggest up to about 30 mL (the full vial) can be given to an adult without benzyl-alcohol toxicity, but one should still use only the amount needed and discard the rest if sterility is lost