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D) HEK-GLP-1R cells were stimulated with either isoproterenol (100 M), compound 2 (1 M) or the two in combination (Co-addition) in the presence of IBMX and 5% DMSO (vehicle)

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High-level coupled-cluster calculation (CCSD(T)) combined with a large aug-cc-pVDZ basis set revealed that compounds 1-3 shared a similar structural backbone, characterized by an aromatic ring-carbonyl-S-pyrimidinone structure