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Profile 3: Poorly Controlled or Unstable Psychiatric Illness Semaglutide and tirzepatide carry no specific psychiatric black box warning, but the FDA's Adverse Event Reporting System (FAERS) contains post-marketing reports of suicidal ideation associated with GLP-1 agents, prompting the FDA to open a signal evaluation in 2023 [7]
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The majority of uric acid is endogenously produced, primarily originating in the liver and subsequently in the small intestine
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