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doi: 10.1097/dcr.0000000000001626 57 KalyanaramanBChengGHardyMOuariOSikoraAZielonkaJet al

Negative Feedback Regulation Importantly, Sermorelin stimulation is subject to physiological regulation through the somatostatin-GHRH axis: when GH and IGF-1 levels rise, this triggers negative feedback at the hypothalamus, stimulating release of somatostatin (also called growth hormone-inhibiting hormone or GHIH) from periventricular hypothalamic neurons

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