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The first question is relatively easy to answer

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CT388-103 was a multi-center, randomized, double-blind, placebo-controlled, parallel-group, dose-finding Phase II study conducted in 469 adults with obesity or who are overweight and have at least one weight-related comorbidity, excluding type 2 diabetes

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However, in states of insulin resistance, these processes are inverted, and there is paradoxical increase in gluconeogenesis and lipogenesis (157)