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Lee M, Rutka JA, Slomovic AR, McComb J, Bailey DJ, Bookman AA J Rheumatol

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The researchers indicate that in mouse models of CKD or heart failure, the overactivation of the kidney-brain neural circuit leads to increased sympathetic nerve activity targeting both the kidneys and the heart (Cao et al., 2023)

Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy