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Dose Titration Schedule Clinical trials established that starting with lower doses and gradually increasing reduces gastrointestinal side effects while maintaining long-term efficacy
Trial STEP 3 (Wadden et al., JAMA 2021) Design Phase 3 / 68 weeks Population 611 adults with obesity + intensive behavior therapy Key result -16.0% body weight (2.4 mg) vs -5.7% placebo
Hydrate aggressively now, not after dehydration causes problems
These dendritic branches might be the primary receivers of GLP-1 signaling, as GLP-1 fibers are denser around the central canal, and GLP-1 also appears to be transmitted via the CSF 55
M.MukhopadhyaI
DJH provides consulting advice on scientific advisory boards for Haleon, TLCBio, Novartis, Tissuegene, Sanofi and Enlivex
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