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In February 2025, Gan & Lee Pharmaceuticals (hereafter referred to as "Gan & Lee," stock code: 603087.SH) unveiled that the first participant was successfully dosed in a large-scale Phase 3 clinical trial (OPTIMUM-2) of Bofanglutide, a bi-weekly glucagon-like peptide-1 receptor agonist (GLP-1RA) independently, in Chinese participant with type 2 diabetes mellitus (T2DM)

doi: PubMed: 23720375

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Also, prostate cancer mouse models showed progression from androgen-dependence to androgen-independence to be associated with an increase in IGF-I and decrease in IGFBP-3, further suggesting their role in cancer aggressiveness (128)

Pauls Hospital and Vancouver General Hospital