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Some skeletal muscles did shrink, on average by about 6%, but this was not enough to account for the overall drop in lean mass
SUMOylation modulates protein stability, subcellular localization, transcriptional activity, synaptic plasticity, and neuronal excitability
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Attaching a fatty acid via a chemical linker to a specific residue on an already-assembled peptide requires controlling the proportion of conjugated versus unconjugated species, detecting and controlling free fatty acid or linker impurities, and monitoring for di- or poly-modification at unintended sites
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