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Chemistry of Materials 28 , 40094016, (2016)

doi: 10.1016/j.jad.2006.08.021 206 PageMJKellDBPretoriusE

Coenraads PJ

These compounds include pyruvate, which can be converted into acetyl-CoA and enter the tricarboxylic acid (TCA) cycle or be used for fatty acid synthesis, and -ketoglutarate, a precursor of glutamate and an intermediate of the TCA cycle

Liver/Kidney/CYP450: High-dose systemic copper chelate therapy requires strict monitoring of ceruloplasmin and unbound serum copper to prevent heavy metal toxicity or Wilson-like hepatic accumulation