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Autophagy 17 , 385401 (2021)
Prucalopride was efficacious in relieving symptoms based on total Gastroparesis Cardinal Symptom Index, subscales of nausea/vomiting, fullness/satiety, and bloating/distention, as well as improvement in the overall Patient Assessment of Upper Gastrointestinal Disorders-Quality of Life score ( Intravenously administered felcisetrag significantly accelerated gastric emptying, small bowel transit and colonic transit compared to placebo in patients with gastroparesis with previously confirmed delayed gastric emptying
Ivermectin inhibits LPS-induced production of inflammatory cytokines and improves LPS-induced survival in mice
FBW7 (F-box and WD repeat domain-containing 7) negatively regulates glucose metabolism by targeting the c-Myc/TXNIP (thioredoxin-binding protein) axis in pancreatic cancer
Its first-in-class mechanism, safety profile, and CNS bioavailability support clinical development for glioblastoma
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