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2024 JAMA Ophthalmology Study Findings The landmark Harvard Medical School study published in JAMA Ophthalmology in July 2024 provided the first rigorous scientific evidence linking semaglutide to elevated NAION risk analyzing 16,827 patients at Massachusetts Eye and Ear and revealing alarming risk multipliers that prompted global regulatory scrutiny

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It is characterized by insulin resistance, wherein peripheral tissues exhibit a diminished response to insulin, eventually resulting in impaired insulin utilization and relative insulin deficiency [3]

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Eligibility criteria include specific BMI thresholds, presence of comorbidities such as type 2 diabetes or cardiovascular disease, and previous weight loss attempts