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Additionally, "some herbal or 'natural' remedies for constipation, like aloe, cascara, or senna-based products are stimulant-based," says Hamilton, "meaning they work by causing the intestines to contract more forcefully." While these supplements can be effective for short-term relief, Hamilton warns that frequent use can lead to cramping, diarrhea, or dependence

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There is a plausible rationale for zinc as supplementation to improve insulin resistance, lipid metabolism and hyperandrogenism in PCOS animals and patients ( Zinc is necessary for many physiological functions including insulin production, storage, and action

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Safety evaluation: The safety of the cream is assessed through acute toxicity tests, long-term toxicity tests, etc., to ensure that it has no toxic or side effects