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In this experimental model, although the blood pressure did not differ in the G6PD-deficient and control rats, the blood pressure surge, elicited by a high-fat diet, was abrogated in the deficient rats
103 Animal studies have reported antidepressant like effects with these drugs
Previous work has reported relatively increased Firmicutes and Proteobacteria and decreased Bacteroidetes in mice on an HFD, regardless of concomitant obesity (weight gain was minimized using a RELM knockout mouse 78 ) 78,79
However, if weight regain occurs primarily through fat accumulation, metabolic health can worsen
This test does not predict exact medication response but may help guide dose titration strategy and symptom-management timing in consultation with your healthcare team