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Summary Definition History and exam Key diagnostic factors presence of risk factors food or stress triggers urinary urgency urinary frequency urinary incontinence nocturia dysuria pelvic-floor pain dyspareunia worsening of symptoms before menses urethral pain bladder neck pain suprapubic pain levator ani pain pain after placement of Foley's catheter Other diagnostic factors fibromyalgia vulvar vestibulitis vulvodynia features of systemic lupus erythematosus migraine features of rheumatoid arthritis features of chronic fatigue syndrome allergies sexual/domestic abuse scrotal or anal pain Risk factors age 20 to 60 years female sex positive family history sexual or domestic abuse white ethnicity Diagnostic investigations 1st investigations to order urinalysis with microscopy and culture vaginal wet prep voiding diary urine cytology Investigations to consider cystoscopy with hydro-distension of bladder bladder biopsy Emerging tests stress protein gene assay urine anti-proliferative factor urine nerve growth factor (NGF) Treatment algorithm non-ulcerative interstitial cystitis ulcerative interstitial cystitis Contributors Authors Kenneth M

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Contraindications and Precautions Because BPC 157 remains experimental, certain groups should be particularly cautious

Injections work faster and are better for people who cant absorb B12 well

Cell hyperplasia & GH/IGF-1 axis Explored in research on IGF-1 receptor signaling and hyperplasia