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In the 12-week extension phase, age averaged about 49 across the 4 study arms, slightly more than half of participants were women, and 47 (73%) were Hispanic

Oct 9: In a relatively rare move, the FDA went against the recommendation of one of its advisory committees, rejecting a bid by Alnylam to expand Onpattro (patisiran)s label to cardiomyopathy of transthyretin-mediated amyloidosis

Its reproducible activity profile supports the establishment of quantitative assays for high-throughput screening, potency determination, and mechanistic evaluation of novel compounds

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and the annual total and chronic rate of change in eGFR