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les personnes atteintes de la maladie de Leber (neuropathie optique hrditaire) : la cyanocobalamine est formellement contre-indique, la mthylcobalamine doit tre privilgie
The four-week intervals at each dose level allow GI adaptation
Functional improvement follows pain reduction by approximately 1 to 2 weeks
Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision
2019 Sep 15;145(6):1499-1503
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