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Beneficial effects of GLP-1 in reducing toxic protein accumulation are hypothesized to occur through the PI3K/Akt inactivation of glycogen synthase kinase 3 beta (GSK3) [82] and a possible GLP-1 mediated upregulation of IDE [83]

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This process depletes cellular NAD+ and S-adenosylmethionine (SAM) two critical molecules for energy metabolism and cellular function

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Roemheld-Hamm, B

Subsequently, the remaining 310 articles underwent a full-text review, which was conducted independently by Bo-Hao Huang and Fei-Yang Xiong to ensure accuracy and consistency