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Finally, the M1-M2 loop of GluK2, forming the intracellular bottom cap and portals, primarily associates with the C-terminal region of Neto2 ( FIGURE 6 4 Gating 4.1 Closed resting state In the closed state, two-fold rotational symmetry is observed between individual ATD dimers and within the ATD dimer-of-dimers arrangement (Figures 3AD), while the TMD displays a pseudo four-fold symmetry
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Further Netherlands research into VIPs mechanisms of action and potential clinical benefits continues to expand our understanding of this important neuropeptide
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