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( 5.5) Adverse Reactions/Side Effects Most common treatment emergent adverse reactions (5% and at least twice that of placebo) include oily spotting, flatus with discharge, fecal urgency, fatty/oily stool, oily evacuation, increased defecation and fecal incontinence

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Biocompatibility At the end of the 6-week experiment, the rats were euthanized using carbon dioxide and tissues (kidneys and liver) were collected for histology

Clinical trials comparing the two drugs directly are already underway at Eli Lilly, and that data will eventually inform switching protocols

Emerging evidence suggests they may also influence neurobiological processes that contribute to addictive behaviors

The challenge is getting enough L-arginine to the endothelial cells where NOS does its work