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Like astrocytes, enteric glia are activated by intracellular calcium via GPCR signaling, which drives GI contractility in mice (McClain et al., 2015)

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Antioxidants 12:123

Hormonal drugs can generate serious adverse effects when used for a long-term treatment

Since NAD+ metabolism generates NADPH for glutathione recycling, and glutathione protects against oxidative damage that depletes NAD+, maintaining both creates a reinforcing cycle of cellular protection

IV treatments may show visible improvements in 24 weeks