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FOXO1 activation leads to the upregulation of both C/EBP and ATF4, which then coordinate to enhance the transcription of target genes, including ChaC1

Stearate (Veg), Hypromellose, Gelatin

We hypothesize that SAC inhibits the E3 ubiquitin ligase activity of KEAP1 through interaction, thereby blocking the ubiquitination-mediated degradation of NRF2, stabilizing the NRF2 protein, and activating the transcription of various protective genes, including antioxidant enzymes

The analysis was supported by grant from the National Research Foundation of Korea grant