It mainly inhibits liver lipid accumulation, which benefits patients with type 2 diabetes
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The use of GLP-1R agonists was associated with fewer intra-articular injections of steroids and a lower cartilage loss velocity from the medial femoral joint, but the direct effects of GLP-1R agonist, apart from the weight loss-mediated pathway, did not reach statistical significance
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Some report even better energy by weeks 20-24 than baseline due to reduced body weight and improved metabolic health
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