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Diabetes 39 , S148S154 (2015)

For comparison, the modified GHRH analog CJC-1295 (specifically the version without DAC, which is what is commonly used in modern clinics) has a longer functional duration that keeps the GHRH stimulus present long enough for a more meaningful, sustained growth hormone pulse to occur

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In addition to liver-derived serum IGF-1 (endocrine), there is strong evidence that locally expressed IGF-1 (autocrine/paracrine) regulates longitudinal bone growth in the growth plate [87,127132]

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