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It is a powerful antioxidant that protects cells from oxidative stress

Individuals with SMIs experience premature and excess mortality, with years of life lost often estimated between 5 and 25 years, largely due to earlier onset and substantially higher rates of CVD

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Under the influence of IL-4 and IL-13 and the interactions between adhesion molecules on B cells (class II MHC molecules: CD80/CD86, CD40, and ICAM-1) and T cells (CD3, CD4, CD28, CD40L, and LFA-1 receptors), B cells switch from expressing IgM, IgG2, and IgG3 to IgG4 and IgE (179)

the second is caused by inflammatory oxidative conditions, which include atherosclerosis, arthritis, rheumatoid arthritis, and probably chronic inflammation (Table 1) [41]

This includes dietary adjustments (smaller, more frequent meals, and avoiding spicy or fatty foods), changing the time of injection, or taking over-the-counter medications to manage side effects