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Modified DPP-4 can not only mask the enzymatic hydrolysis site of DPP-4 but also bind closely with albumin to reduce renal excretion and prolong the half-life

doi: 10.1210/jc.2018-00070 Marso SP, Bain SC, Consoli A, et al

Heating pads, warm baths, or hot compresses should be avoided for at least 24 to 48 hours after the bruise forms