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Compare Wegovy, Zepbound, and Ozempic Treatment Options Through Ro Tirzepatide: Zepbound for Enhanced Weight Loss Through Dual Receptor Activation Zepbound (Tirzepatide): FDA-Approved Dual GLP-1/GIP Receptor Agonist FDA Approval Status : According to FDA documentation, Zepbound (tirzepatide) received approval on November 8, 2023, for chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity, to be used as an adjunct to reduced-calorie diet and increased physical activity

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[4] Clinical trials [edit] Retatrutide has been studied in a phase 2 trial involving adults without diabetes but with obesity or preobesity (overweight)