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If IGF-1 remains too low or jumps too high, it may signal under- or over-treatment

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Redox control of protein-DNA interactions: from molecular mechanisms to significance in signal transduction, gene expression, and DNA replication

Drug Dev Res 2009;70:472-80

For example, MYC and KRAS overexpression are involved in diverse metabolic changes, including increased glucose uptake and rewiring of GSH biosynthesis [10, 11]