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The integration of ferroptosis-targeted strategieseither through small-molecule inducers, pathway modulators, or combination therapiesmay offer novel avenues to overcome drug resistance and improve treatment outcomes in MM and related disorders

A recent clinical trial offers new insight

Acta Biol (Szeged)

Sections were incubated with Alexa Fluor goat anti-rabbit IgG and Alexa Fluor goat anti-mouse IgG (1:500, Life Technologies, Grand Island, NY) at RT for 1 h and counterstained with DAPI

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The proposed mechanism described in papers that were later retracted is that it potentiates hepatocyte growth factor (HGF) signaling at the c-Met receptor, driving dendritic spine formation and synaptogenesis