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One recent study used CRISPRa to successfully restore neuronal excitability and electrophysiological deficits in Scn2a +/- mice to wild-type levels, an effect that persisted until at least 3 and 8 months, respectively [78]

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Intranasal Delivery of Interferon--Loaded Nanoparticles Induces Control of Neuroinflammation in a Preclinical Model of Multiple Sclerosis: A Promising Simple, Effective, Non-Invasive, and Low-Cost Therapy